2+ day, 46+ min ago  (237+ words) Introduction Multiple primary malignant neoplasms (MPMNs) are increasingly recognized due to'improved diagnostics and prolonged survival. Predisposing factors include genetic mutations, lifestyle, and environmental exposures. This study analyzes the clinic-pathological characteristics of female patients diagnosed with synchronous or metachronous bowel and…...

1+ day, 46+ min ago  (313+ words) Pigment dispersion syndrome/pigment dispersion glaucoma (PDG) has no definitive cure and can cause vision loss in young myopes. Backward bowing of the iris can lead to rubbing of the pigmented epithelium against lens zonules and accumulation of pigment, obstructing…...

1+ day, 46+ min ago  (181+ words) Spinal cord stimulation (SCS) is an established therapy for chronic pain, primarily used for analgesia; however, its broader physiologic effects remain poorly characterized. This retrospective observational cohort study evaluated whether SCS implantation was associated with changes in appetite and body…...

3+ day, 46+ min ago  (318+ words) Aerobic (AT) and resistance training (RT) are well established as effective strategies for lowering blood pressure (BP) in patients with hypertension; however, evidence on the impact of combined training (CT; AT and RT) on BP remains limited. We therefore conducted…...

1+ day, 46+ min ago  (310+ words) Background Successful liberation from mechanical ventilation (MV) requires a systematic assessment of readiness for extubation. The 2015 Japanese Society of Intensive Care Medicine guidelines recommend daily spontaneous awakening trials (SATs) paired with spontaneous breathing trials (SBTs) and standardized risk stratification for post-extubation…...

2+ day, 46+ min ago  (251+ words) Ochronosis is a rare metabolic disorder caused by alkaptonuria, resulting in the accumulation of homogentisic acid within connective tissues and progressive degeneration of large joints. Clinical presentation often mimics primary osteoarthritis, leading to delayed or missed diagnosis. We report the…...

1+ day, 14+ hour ago  (305+ words) Background Surgical site infections (SSIs) are important postoperative complications associated with prolonged hospitalization, increased antimicrobial exposure and higher healthcare costs. Anaerobic bacteria are recognized contributors to SSIs but are often underdetected in routine laboratory practice due to challenges in specimen…...

2+ day, 46+ min ago  (211+ words) Oral mucosal melanoma is a rare malignancy of the oral cavity and a small subset of melanomas overall, characterized by an aggressive clinical course and diagnostic challenges. These challenges are particularly pronounced in amelanotic variants due to the lack of…...

2+ day, 46+ min ago  (173+ words) Traditional osteoarthritis (OA) treatment focuses on symptom management, including nonsteroidal anti-inflammatory drugs (NSAIDs), duloxetine, intra-articular glucocorticoids, or surgical intervention. Unfortunately, these approaches may provide inadequate symptom relief or can be contraindicated in patients with comorbidities such as cardiac issues, diabetes,…...

3+ day, 46+ min ago  (131+ words) Primary retroperitoneal squamous cell carcinoma (SCC) is an exceptionally rare malignancy. Here, we present the case of a 55-year-old female with a retroperitoneal tumor who underwent complete surgical resection. Histopathological examination confirmed SCC with no evidence of an alternative primary…...